Antibacterial Screening Of The Culture Of Endophytic Fungal Extracts Isolated From Cinnamon Stick (Cinnamomum burmanni [Nees & T. Nees] Blume)

Pathogenic bacterial resistance to antibacterial agents used in the treatment of recent formal systems haveundergone significant increase. It is necessary to get a source of new antibacterial agents to overcome resistance.Endophytic fungi have been known as one of the organisms that have the ability to produce a variety of bioactivemetabolites. In this study, 26 endophytic fungi have been isolated from various parts of Cinnamomum burmanniiplant. The results of antibacterial activity screening of endophytic fungal extracts by TLC-bioautography methodwithout elution showed that as many as 18 extracts inhibited the growth of Staphylococcus aureus InaCC-B4 withthe diameter of inhibition zone (DIZ) were in the range of 5.00 to 16.00 mm. On the other hand, the number ofextracts that could inhibit the growth of Escherichia coli InaCC-B5 were 24 extracts with the DIZ were in the rangeof 4.00 to 28.00 mm. A detailed analysis of eluted TLC-bioautography method showed the chemical compoundsof extracts that were responsible for antibacterial activity.Keywords : Cinnamomum burmannii, endophytic fungi, antibacterial, TLC-bioautography. Teknologi Indonesia 38 (1) 2015: 33–41, tahun 2015