Badan Riset dan Inovasi Nasional
07-11-2022
13-08-2024
5a9f0f0b-dcbd-43a4-b264-f37dbc11c807
In our course of screening for secondary metabolite derived from marine bacteria...
Base to the purpose of the finding a new source of antifungal compounds origin f...
Marine Cosmeceuticals: Trends and Prospects is a consolidated overview of the ma...
In the previous study, we have isolated marine microbes which have capability to...
Indonesia is often referred to as the world\'s largest archipelago, a name which...
INFORMASI: Data berikut ini masih dalam proses pemenuhan Prinsip SDI.
Psammaplysin Derivatives from The Balinese Marine Sponge Aplysinella strongylata
Twenty-one new psammaplysin derivatives (4−24) exhibiting a variety of side chains, as well as six previously known psammaplysins, were identified from the Indonesian marine sponge Aplysinella strongylata. The double bond on the side chain of the fatty acid-containing psammaplysins was located by GC-MS analysis of the fatty acid methyl esters and their pyrrolidide derivatives. HPLC and Mosher ester studies confirmed that the isolated metabolites possessing a 19-OH substituent were mixtures of diastereomers. Selected compounds (4, 5, 7, 8, 12, 18, and 22) were screened for in vitro activity against chloroquine-sensitive (3D7) P. falciparum malaria parasites. Of the new psammaplysins, 19-hydroxypsammaplysin E (4) showed the best antimalarial activity, with an IC50 value of 6.4 μM. Journal of Natural Products, Vol. 75. Hal. 2132-2143