Antifungal compounds derived from sponge Aaptos Sp. Collected from Pari Island

Base to the purpose of the finding a new source of antifungal compounds origin from Indonesian marine resources, the screening of sponges extract collected from Pari Island was done. Several of methanol extracts showed active against the pathogenic fungus Tricophyton rubrum and Candida albicans. One of the potent extract was S6-P3 that identified as Aaptos sp. This extract showed the potent activity with the diameter inhibition approximately 32,05 mm against Tricophyton rubrum and 12,05 mm against Candida albican. Separation technique of the active compounds was done using open column chromatography and the isolated compounds characterized using Gas Chromatography-Spectroscopy Mass (GC-MS). The GC-MS data analysis proved that the active fraction contained the antibiotics aaptamine and demethylaaptamine Ilmu Kelautan Februari 2010.Vol.2. Edisi Khusus :353-361